Fecal Lipid Content, Serum Lipid Profile, and Intra-Abdominal Fat Accumulation in Normal Rats Supplemented with Rice Bran Oil

  • Hana Fitria Navratilova Departement of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor 16680, Indonesia
  • Evy Damayanthi Departement of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor 16680, Indonesia
  • Romadhony Ardiansyah Departement of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor 16680, Indonesia
  • Intan Nur Fitriyana Departement of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor 16680
  • Retno D. Soejoedono Department of Animal Disease & Veterinary Public Health, Faculty of Veterinary Medicine, IPB University, Bogor 16680, Indonesia
  • Maggy Thenawidjaja Departement of Food Science and Technology, Faculty of Agricultural Technology, IPB University, Bogor 16680, Indonesia
Keywords: cholesterol, faecal lipids, normal rat, orlistat, rice bran oil

Abstract

This study aimed to investigate the mechanism of rice bran oil on altering lipid absorption and blood lipid level in normal rat. Male Sprague Dawley rat age 3 months old, weighted 250–300 g were grouped into three groups: control (aquabidest 1 ml), orlistat (2.16 mg / 200 g body weight), and rice bran oil (1.04 mg γ-oryzanol / 200 g body weight). The intervention was given through oral gavage, daily for 28 days. Indicators observed were growth performance, total cholesterol and serum triglyceride levels, lipid levels in feces, and accumulation of intra-abdominal fat. The results showed that the treatment did not significantly affect body weight gain. Fecal lipid levels of orlistat, rice bran oil and control group respectively were 0.19g; 0.17g and 0.13 g (p<0.05), while the percentage of indigestible lipids for orlistat, control and rice bran oil group were 26%, 17% and 13% respectively (p<0.05). Total cholesterol and serum triglyceride levels in rice bran oil group were significantly lower than controls. Rice bran oil did not significantly affect the percentage of total intra-abdominal fat and the weight of the heart and kidney (p>0.05). The intervention of rice bran oil was shown to reduce blood cholesterol and triglyceride levels in normal mice and did not accumulate intra-abdominal fat. The results suggest that rice bran oil might have an effect on blood lipid regulation but not by preventing lipid absorption.

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Published
2020-07-30
How to Cite
Navratilova, H. F., Damayanthi, E., Ardiansyah, R., Fitriyana, I. N., Soejoedono, R. D., & Thenawidjaja, M. (2020). Fecal Lipid Content, Serum Lipid Profile, and Intra-Abdominal Fat Accumulation in Normal Rats Supplemented with Rice Bran Oil. Jurnal Gizi Dan Pangan, 15(2), 119-124. https://doi.org/10.25182/jgp.2020.15.2.119-124
Section
Articles